Synthesis of Fibrin Clot from Fibrinogen Platelet Rich Plasma (PRP) for Scaffold Applications

Siti Fauziyah Rahman

doi:10.62146/ijecbe.v1i1.11

Authors

Siti Fauziyah Rahman

DOI:

https://doi.org/10.62146/ijecbe.v1i1.11

Keywords:

Fibrin, Fibrinogen, PRP, Scaffold

Abstract

Platelet-rich plasma (PRP), which contains fibrinogen, is activated by the addition of thrombin and calcium chloride to create fibrin clots. Fibrin is a natural biopolymer that can be applied for medical applications. This study aims to synthesize fibrin clots from fibrinogen platelet-rich plasma for scaffold applications. The optimum amount of fibrin clot can be obtained by varying the ratio of PRP to a mixture of CaCl₂ with the variation of 9:1, 10:1, and 11:1. The highest fibrin clot produced was 5.925 ml with 5.5% CaCl₂.

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